ackground and the Method : Abnormality of p53 is the most frequent genetic derrangement in the malignant diseases. Some oncogens like myc or erb B2 are known to be a poor prognostic marker in lung cancer, but the relationship of p53 gene mutation
and
the survival is controversial. Immunohistochemical staing can detect only mutant p53 protein because of markedly prologed half life of mutant p53 protein compared to wild type p53. So, using Pab 1801, we performed the immunohistochemical stain on
38
resected priformed nonsmall cell lung cancer specimens and analyzed the relationship between the expression of p53 protein and the clinical parameters including the survival.
Result : p53 protein was detected in 55% of total 38 patients (56% of 25 squamous
carcinoma and 70% of 10 adenocarcinoma). P53 protein was positive in 50% of stage Ⅰ, 36%
of stage Ⅱ, 78% of stage Ⅲa, and 50% of stage Ⅲb. Using the Kaplan-Meier method and
SAS statistics program, the survival of p53 protein positive patients was significantly low
(p=0.0402) compared to the survival of p53 protein negative patients. The surgical stage also
had the significant correlation with the survival.
Conclusion : The presence of p53 mutation is a poor prognostic marker.
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